Detection of Early Markers for Sjögren Syndrome in Dry Eye Patients

rheumatologist dry eye sjogrensEstimates are approximately 4 million Americans suffer from Sjögren’s Syndrome (SS) or about 1 in 10 of your dry eye patients. The hallmark symptoms are dry eye and dry mouth but Sjögren’s may also cause dysfunction of other organs such as the kidneys, gastrointestinal system, blood vessels, lungs, liver, pancreas, and the central nervous system. Patients may also experience extreme fatigue and joint pain and have a higher risk of developing lymphoma. We must do a better job of finding these patients early as unfortunately Sjögren’s can often be overlooked or misdiagnosed.

On average, it takes nearly 3.9 years to receive a diagnosis of Sjögren’s. in the December 2014 Cornea , Dr Ken Beckman in “Detection of early markers for sjogren syndrome in dry eye patients” presents a review of 3 patients with a history of dry eye utilizing standard ocular surface exam testing such as corneal staining, tear break up time as well as tear osmolarity testing with the TearLab Osmolarity System. Additionally, he utilized laboratory testing including the Sjo diagnostic panel by Nicox Inc for the presence of novel autoantibody markers linked to the early stages of SS. Aggressive treatment regimens and referral to Rheumatology can make a significant improvement in these patients lives.

Read more here.

Author: Ken Beckman, M.D.

Changing Dry Eye Disease in Your Practice: An Administrator’s Perspective


While it can be challenging to incorporate new instruments into a busy practice, the latest supplement in Ophthalmic Professional is proof that with a little dedication, team work and communication, administrators and office managers can achieve … [Continue reading]

Change in Tear Film Characteristics in Visual Display Terminal Users

Broker working on laptop visual terminal

More and more peer review evidence is confirming that video display terminal (VDT) users are more inclined to have dry eye disease (DED). In the recent Epub ahead of print from the EJO, Yazici et al. present additional evidence in their work titled … [Continue reading]

Modification of Timolol Release From Silicone Hydrogel Model Contact Lens Materials Using Hyaluronic Acid

Contact Lenses

Hyaluronic Acid (HA) also known as hyaluronate is a mucopolysaccharide that occurs naturally in our bodies. It binds to water which results in a viscous gel and has been involved in literally thousands of trials in ophthalmology and orthopedics due … [Continue reading]

Oral Azithromycin Versus Doxycycline in Meibomian Gland Dysfunction: A Randomised Double Masked Open Label Clinical Trial

Pills Spilling out of Pill Bottle

How often do you offer oral prescription antibiotic therapy to your meibomian gland dysfunction (MGD) patients? Many of us have become quite surprised by the effect we see in our dry eye disease (DED) patients we treat with oral OTC products e.g. … [Continue reading]

Mimetogen Pharmaceuticals Announces Topline Results of Its Second Clinical Study with MIM-D3 for Dry Eye Syndrome

Senior doctor/scientist using his tablet computer at work (color

Well, we may have a new drug for our dry eye disease (DED) patients sometime in the near future. However, the press release from Sept. 9, 2014 is not absolutely clear: "Mimetogen Pharmaceuticals Announces Topline Results of Its Second Clinical Study … [Continue reading]

Evaluation of Tearing in Oculoplastics Assisted by Tear Osmolarity Measurement.


Since we now have several point-of-care tests available to assist in diagnosing and managing dry eye disease (DED) patients, which will certainly become standard-of-care in the near future, it is interesting to see this publication in the October … [Continue reading]

Prevalence and Risk Factors of Dry Eye Disease in a British Female Cohort

Senior Woman Applying Eye Drops

I am not a big fan of questionnaires as often times they can provide confounding factors. However in the Sept. 2014 British Journal of Ophthalmology, a publication titled "Prevalence and risk factors of dry eye disease in a British female cohort” by … [Continue reading]

Tear Osmolarity Testing and the Contact Lens Patient

tear osmolarity testing protocol dave geffen.fw

In the latest edition of 'In My Practice', Dr. David Geffen explains how Tear Osmolarity Testing can be a great asset for contact lens patients. Due to the dry eye symptoms and discomfort contact lenses can cause, patients who wear them are being … [Continue reading]

Antioxidant and Inflammatory Cytokine in Tears of Patients with Dry Eye Syndrome Treated with Preservative-free Versus Preserved Eye Drops

two medical bottles

In the busy rush of daily practice, we sometimes forget about the importance of non preserved (NP) or Preservative-free (PF) drops for our dry eye disease (DED) patients. In the July 2014 volume of Investigative Ophthalmology and Vision Science … [Continue reading]