Dry Eye Disease After Refractive Surgery: Comparative Outcomes of Small Incision Lenticule Extraction VS LASIK

Eye OperationOne of the newest techniques in refractive surgery is the Small Incision Lenticule Extraction (SMILE) which utilizes a femtosecond laser to create an instra-stromal lenticule that is then removed through a small corneal incision. Significant dry eye disease (DED) symptoms following LASIK is well documented; and in the Ophthalmology 2014 Nov 22 Epub ahead of print, Denoyer et al investigate “Dry Eye Disease after Refractive Surgery: Comparative Outcomes of Small Incision Lenticule Extraction versus LASIK”.

Thirty patients scheduled for bilateral myopic SMILE and 30 age-, sex-, and refraction-matched patients scheduled for bilateral myopic LASIK were enrolled and followed for 6 months. All patients underwent a complete evaluation at 1 and 6 months including Ocular Surface Disease Index [OSDI]), tear film breakup time [TBUT], Schirmer I test, corneal staining and tear osmolarity measurements, together with an overall severity score. Function and morphology of the corneal innervation were evaluated by corneal esthesiometry and subbasal nerve imaging using in vivo confocal microscopy (IVCM). The main outcome was dry eye disease and corneal nerve innervation. They concluded the SMILE procedure has a less pronounced impact on the ocular surface and corneal innervation compared with LASIK, further reducing the incidence of dry eye disease and subsequent degradation in quality of life after refractive surgery. They also found quality of life, TBUT and osmolarity were significantly impaired in the LASIK group compared to the SMILE group.

Read the abstract here

Correlation Between Tear Film Osmolarity, Dry Eye Disease and Rheumatoid Arthritis

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With the recent advent of lab testing in eye care Sjogrens Syndrome (SS) has received much needed attention; but we must not forget about our patients having other autoimmune diseases that may well suffer from dry eye disease with no previous … [Continue reading]

Open Your Eyes to Osmolarity Testing!

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In the latest edition of our In My Practice series, Dr. Alan Panzer discusses the numerous benefits of utilizing tear osmolarity in clinical practice. Dr. Panzer describes helpful strategies for determining which patients to test as well as how to … [Continue reading]

Detection of Early Markers for Sjögren Syndrome in Dry Eye Patients

rheumatologist dry eye sjogrens

Estimates are approximately 4 million Americans suffer from Sjögren’s Syndrome (SS) or about 1 in 10 of your dry eye patients. The hallmark symptoms are dry eye and dry mouth but Sjögren’s may also cause dysfunction of other organs such as the … [Continue reading]

Changing Dry Eye Disease in Your Practice: An Administrator’s Perspective


While it can be challenging to incorporate new instruments into a busy practice, the latest supplement in Ophthalmic Professional is proof that with a little dedication, team work and communication, administrators and office managers can achieve … [Continue reading]

Change in Tear Film Characteristics in Visual Display Terminal Users

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More and more peer review evidence is confirming that video display terminal (VDT) users are more inclined to have dry eye disease (DED). In the recent Epub ahead of print from the EJO, Yazici et al. present additional evidence in their work titled … [Continue reading]

Modification of Timolol Release From Silicone Hydrogel Model Contact Lens Materials Using Hyaluronic Acid

Contact Lenses

Hyaluronic Acid (HA) also known as hyaluronate is a mucopolysaccharide that occurs naturally in our bodies. It binds to water which results in a viscous gel and has been involved in literally thousands of trials in ophthalmology and orthopedics due … [Continue reading]

Oral Azithromycin Versus Doxycycline in Meibomian Gland Dysfunction: A Randomised Double Masked Open Label Clinical Trial

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How often do you offer oral prescription antibiotic therapy to your meibomian gland dysfunction (MGD) patients? Many of us have become quite surprised by the effect we see in our dry eye disease (DED) patients we treat with oral OTC products e.g. … [Continue reading]

Mimetogen Pharmaceuticals Announces Topline Results of Its Second Clinical Study with MIM-D3 for Dry Eye Syndrome

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Well, we may have a new drug for our dry eye disease (DED) patients sometime in the near future. However, the press release from Sept. 9, 2014 is not absolutely clear: "Mimetogen Pharmaceuticals Announces Topline Results of Its Second Clinical Study … [Continue reading]

Evaluation of Tearing in Oculoplastics Assisted by Tear Osmolarity Measurement.


Since we now have several point-of-care tests available to assist in diagnosing and managing dry eye disease (DED) patients, which will certainly become standard-of-care in the near future, it is interesting to see this publication in the October … [Continue reading]