Ocular Surface Disease Index & Tear Osmolarity as Markers of Ocular Surface Dysfunction in Video Terminal Display Workers

video display workersAnother great publication just out in the July issue of the American Journal of Opthalmology continues the focus on patients in the workplace having to deal with dry eye disease (DED). A few weeks ago we showed workers using video display terminals (VDT) for long periods can significantly reduce Mucin 5AC leading to physiologic damage to the ocular surface. This latest pub by Fenga et al, titled “Comparison of Ocular Surface Disease Index and Tear Osmolarity as Markers of Ocular Surface Dysfunction in Video Terminal Display Workers” compared the Ocular Surface Disease Index (OSDI) questionnaire and tear osmolarity using the TearLab Osmolarity System to evaluate ocular surface alterations in VDT users. They included 64 workers and also evaluated tear film break-up time (TBUT), fluorescein corneal stain and assessed for meibomian gland dysfunction (MGD).

The study design required subjects to have at least 2 altered signs of these three signs to be classified as having ocular surface dysfunction (OSD) or not. TearLab is a point of care CLIA Waived lab device which requires only a 50 nanoliter sample of tear that provides the clinician tear osmolarity results for both eyes in less than one minute. The ROC curve (AUC) for osmolarity (from 0.71 to 0.86) showed, for all the classification variables considered, statistically significantly higher values than those obtained with OSDI (from .51 to .58). Tear osmolarity also showed correlation with staining and ocular surface dysfunction and inversely with TBUT. The found no correlation between OSDI and the parameters considered. The study conclusion is “tear osmolarity (TO) can be considered a more reliable test then OSDI when screening VDT users for possible ocular surface alterations”.

Read more here.

Authors: C. Fenga et al.

Tear Osmolarity: the Key to Gauging Response to Dry Eye Disease Therapy


In this new article, Dr. Mitchell Jackson discusses why he believes measuring a patient's tear osmolarity is the key to gauging their response to Dry Eye Disease therapies. Dr. Jackson further elaborates on how continuously monitoring this response … [Continue reading]

Understanding New Insights on Patient Experiences After Lasik

Laser Eye Surgery

Have you noticed that patients considering refractive surgery (PRK or LASIK) or intraocular lenses (IOL) have huge expectations and very little concern about postop complications? As well, what are you doing these days in preoperative counseling and … [Continue reading]

Sleep Deprivation Reduces Tear Secretion and Impairs the Tear Film

insomnia with clock in the night. woman can not sleep.

Sleep deprivation (SD) can cause a number of issues with our body not just physically but also physiologically. A new publication in the latest IOVS Journal Volume 55 titled "Sleep Deprivation Reduces Tear Secretion and Impairs the Tear Film” by … [Continue reading]

Clinical Results on the Feasibility & Quality of Aberrometry-based Intraoperative Refraction During Cataract Surgery

treatment of a cataract by a surgical method

Intraoperative wavefront aberrometry (IWA)-based refraction may not provide reliable or consistent measurements and may not be ideally suited for guiding the surgical refractive plan for patients undergoing cataract surgery, according to a new … [Continue reading]

Implementing Osmolarity Testing in a Large Practice

nancy fairbrother.fw

Ophthalmic Consultants of Long Island (OCLI) is a multi-specialty ophthalmology practice with over 30 doctors and 11 different locations. The Director of Business Development at OCLI, Nancy Fairbrother, has been responsible for marketing, … [Continue reading]

Alteration of Tear Mucin 5AC in Office Workers Using Visual Display Terminals

dry eyes computer screen

Are you taking time to offer a questionnaire for your patients asking questions about dry eye disease (DED) and associated medications, ceiling fans, and other activities including the number of hours worked on a computer? Numerous studies have … [Continue reading]

Adding a Dry Eye Center of Excellence

marg mcdon.fw

In July where we recognize the importance of diagnosing dry eye disease (DED) and sjogren’s syndrome (SS), according to Dr Marguerite McDonald “Dry eye is much more prevalent than previously recognized, and if left untreated, it profoundly impacts … [Continue reading]

OphthaliX Provides an Update on its Clinical Developments and Strategic Plans


Another one bites the dust! Today, June 9, 2014 Can-Fite Bio Pharma’s subsidiary “OphthaliX” announced termination of their pursuit for the drug (CF101) for the treatment of dry eye disease (DED). As you may recall in Dec. 2013 the company announced … [Continue reading]

Sjögren Syndrome: Looking Deeper into Dry Eye

sjogren's rubbing eyes

Recently there has been more attention given to the importance of eye care providers to be on the look-out for patients suffering from Sjögren(’s) Syndrome (SS); and rightly so. This is a full blown multi-system disease and not just a minor condition … [Continue reading]